Acemannan is considered the most researched natural molecule in history. Over 700 peer-reviewed studies backed by 130 worldwide patents and 30 years of testimonials. By 1994, Carrington Laboratories had spent $100 million in their discovery and stabilization of Acemannan.
Now I’m personally challenged to be patient with the process of marinating this incredible information into the people I know and love. What I find is that many people still treat this nutritional technology like it’s just another bottle on the shelf at the health food store. Though, listen closely, Acemannan cannot be found on a shelf at the health food store.
But it is safe to say that there are probably 240 million people in the United States alone who could put Acemannan to good use right this second because of immunodeficiency and related health problems.
And another group that could use its impact are the 7 million children who die yearly because of complications from malnutrition and who are a vital part of our mission. They depend on our success.
Among all the data I can access, I’m going to narrow it down to a single question. Of all the great things that Acemannan contributes, what is its absolute most desired effect? Well, if you’re like me and you’re convinced, and I hope you are, that your immune system is the best thing that’s ever happened to you and has kept you alive this long, despite how we have ignored it, abused it, or taken it for granted, then the most desired effect you and I hope for is macrophage activation. That’s what the largest body of research reveals concerning Acemannan.
Now, what is a macrophage? The macrophage, which means big eater, are the large white blood cells made in the bone marrow. They regulate the immune modulating functions of the immune system. They are vital. They facilitate wound healing and infection control and serve to detect and eliminate foreign antigens or microorganisms that come into the gut. 70 to 80% of all macrophages in your body and in your immune system are housed in the gut. That’s where the front line of defense takes place. The gut is the epicenter of your immune system.
Acemannan was discovered in 1985 and was taken to market in 1994. When it comes to measuring Acemannan and breaking it down into its quantifiable parts, the chemical structures therein are measured in a unit of measurement called a dalton. I bring this up to create some perspective here. Acemannan molecules can go from 1,000 daltons of molecular weight to a few million daltons of molecular weight. So obviously, that’s a very wide range of structures.
These structures are divided into three sizes that have different effects on human physiology:
- Short chains – bioavailable, that is, they get into the bloodstream.
- Medium chains – activate the immune system.
- Long chains – serve as prebiotics, mostly fiber that feeds friendly bacteria in your gut. This also creates an environment for conversion to short chain fatty acids with their many beneficial effects, including a significant contribution to colon health.
In 2005, there were nine scientists in Korea who also were asking the same question. What is the most desired effect of Acemannan? However, they went a little further with the question, like good scientists are inclined to do, and they asked if they could identify the optimal molecular size of modified aloe poly-saccharides with maximum immunomodulatory activity. In other words, in smarter than a fifth grader style, which sizes of these Acemannan’s actually did the best in turning on the immune system? They determined that that would be a good thing to know if your objective is to turn on the immune system, which is the most desired effect. Have I said that already?
Here is what they found. I’ll quote from the research, and on the next slide, I’ll provide an expansion of scientific definitions so you can pause the video and study it further. The study concluded, we found that polysaccharides between 400 and 5 kilodaltons, K representing the term for 1,000, exhibit the most potent macrophage activating activity as determined by increased cytokine production, nitric oxide release, expression of surface molecules, and phagocytic activity. In accordance with the in vitro activity, polysaccharides between 400 and 5 kilodaltons also exhibited the mostpotent anti-tumor activity in vivo. Well, that sounds like good news. Here’s the slide I mentioned. , Acemannan between 5,000 and 400,000 daltons exhibits the most macrophage activation activity. They found the sweet spot. So polysaccharides below 5,000 daltons or above 400,000 daltons showed minimal immune activating results, though they did make other significant nutritional contributions. There’s nothing about Acemannan that’s wasted.
So now, for the first time in history, though the first iteration of Acemannan has been on the market for 11 years at that point and was gaining a positive reputation, scientists knew exactly which molecular weights of Acemannan were achieving the desired effect. Now that might not seem too important to you and me, but it got the attention of a certain Dr. Santiago Rodriguez. Yes, I have a picture of Dr. Rodriguez and myself. But who is he? He’s a PhD organic chemist who incidentally developed the first iteration of Acemannan and that changed lives all over the world. He was the one who designed the processing for the stabilization of Acemannan.
Dr. Rodriguez looked at this new scientific discovery from Korea with a great amount of interest and tapped its insight. But first, he determined to take the first iteration of Acemannan and break it down into its various molecular weights. You know, the Dalton thing. To see what it looked like. And this is what he found. Of course, there are other ingredients that exist in the solids of aloe vera, not just Acemannan. This would include trace elements, peptides, etc.
Dr. Rodriguez revealed then what he found in the first iteration: for every gram, 10.2% was Acemannan. He then researched, based on the new science, of that 10%, how much falls into the category of immune activation. 4% of the total composition activated macrophages. And then he determined how much is bioavailable that absorbs into the bloodstream. A little less than 2%. So this is the basic first iteration of Acemannan.
However, as successful and as efficacious as the first version of Acemannan has been, he wondered if he could improve on that composition. So he went to work. He was able to double the amount of Acemannan per gram to almost 20%. In terms of the immune activating fractions, and remember that’s the most desired effect, it went from 4% to 18% of each gram of composition. 4.5 times increase in immune activation. And look at the smallest chains, which are absorbable into the bloodstream. It went from 2% to almost 10%. More than 5 times increase in bioavailable Acemannan.
Dr. Rodriguez’s intention was to license this technology to some company who could take it to the world. That’s when MannaRelief sat down with him and explained their Social Business 3.0 initiative, which included taking it to the global market, but with a commitment of matching the nutrition and sending it to the world’s most vulnerable children to save lives. Dr. Rodriguez loved the idea and donated the exclusive licensure rights of this technology to MannaRelief and the Hope Movement. To say that he is a friend of the malnourished of the world is an understatement.
One day my curiosity got the best of me, and I made inquiry into what a license of this kind of technology might be worth. In 1994, it was worth $2 million. So it’s likely to be worth even more 30 years later, especially in consideration of its efficacy and market success during that time.
This second iteration, this advanced technology of nature’s most efficacious immune-supporting molecule, is exclusively distributed on the Social Business 3.0 platform. And you should know more. Click on the links below and access important information.
Meanwhile, this is Tony McWilliams. I hope you will always be careful to maintain good works to meet urgent needs and become heroes to your generation.
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